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The Potential Functions and Mechanisms of Oat on Cancer Prevention: A Review
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-11-14 , DOI: 10.1021/acs.jafc.2c06518
Xinping Li 1 , Linyue Zhou 1 , Yonghui Yu 1 , Jingjie Zhang 1 , Jing Wang 1 , Baoguo Sun 1
Affiliation  

Oat is classified as a whole grain and contains high contents of protein, lipids, carbohydrates, vitamins, minerals, and phytochemicals (such as polyphenols, flavonoids, and saponins). In recent years, studies have focused on the effects of oat consumption on reducing the risk of a variety of diseases. Reports have indicated that an oat diet exerts certain biological functions, such as preventing cardiovascular diseases, reducing blood glucose, and promoting intestinal health, along with antiallergy, antioxidation, and cancer preventive effects. At present, cancer is the second leading cause of death worldwide. The natural products of oat are an important breakthrough for developing new strategies of cancer prevention, and their ability to interact with multiple cellular targets helps to combat the complexity of cancer pathogenesis. In addition, the comprehensive study of the cancer prevention activity and potential mechanism of oat nutrients and phytochemicals has become a research hotspot. In this Review, we focused on the potential functions of peptides, dietary fiber, and phytochemicals in oats on cancer prevention and further revealed novel mechanisms and prospects for clinical application. These findings might provide a novel approach to deeply understand the functions and mechanisms for cancer prevention of oat consumption.

中文翻译:

燕麦预防癌症的潜在功能和机制:综述

燕麦被归类为全谷物,含有高含量的蛋白质、脂质、碳水化合物、维生素、矿物质和植物化学物质(如多酚、类黄酮和皂苷)。近年来,研究集中于食用燕麦对降低多种疾病风险的影响。研究表明,燕麦具有预防心血管疾病、降低血糖、促进肠道健康等生物学功能,并具有抗过敏、抗氧化、防癌等作用。目前,癌症是全球第二大死因。燕麦的天然产物是开发癌症预防新策略的重要突破,它们与多种细胞靶标相互作用的能力有助于对抗癌症发病机制的复杂性。此外,对燕麦营养素和植物化学物质的抗癌活性和潜在机制的综合研究已成为研究热点。在这篇综述中,我们重点关注了燕麦中多肽、膳食纤维和植物化学物质在癌症预防中的潜在功能,并进一步揭示了新的机制和临床应用前景。这些发现可能提供一种新方法来深入了解食用燕麦预防癌症的功能和机制。
更新日期:2022-11-14
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