Iridoid Glycosides and Flavonoids Isolated from the Twigs and Leaves of Callicarpa nudiflora and Their Anti-Inflammatory Activities,Chemistry & Biodiversity

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Iridoid Glycosides and Flavonoids Isolated from the Twigs and Leaves of Callicarpa nudiflora and Their Anti-Inflammatory Activities
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-14 , DOI: 10.1002/cbdv.202200993
Hao Wang _{1,

2} , Hao-Yan Dong ₁ , Yan-Fang Liu ₂ , Ji-Lei Liang ₁ , Hui-Sheng Liu ₁ , Qin-Shi Zhao ₃ , Ping-He Wei ₁

Affiliation

A new iridoid glycoside, named 6′-O-trans-feruloyl-8-epiloganic acid, together with fifteen known compounds were isolated from the twigs and leaves of Callicarpa nudiflora, a traditional Chinese medicine to treat inflammatory-related diseases. Their structures were identified by comprehensive spectroscopic analysis and comparison with reported data. Bioassay results revealed that twelve of the isolates could obviously inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cell lines with IC₅₀ values from 0.64 to 38.72 μM. Among them, compounds 1 (3.27 μM), 6 (5.23 μM), 13 (1.56 μM) and 14 (0.64 μM) exhibited significantly higher activities than that of the positive control (27.13 μM). Additionally, it was supposed that the presence of the carboxy group at the C-4 position of iridoid glycosides and glycosylation at C-3 position of flavonoids might impact their inhibitory activities against NO production.

中文翻译：

从裸花紫珠枝叶中分离的环烯醚萜苷和黄酮类化合物及其抗炎活性

一种新的环烯醚萜苷，命名为6'- O - trans- feruloyl -8-epiloganic acid，连同 15 种已知化合物从Callicarpa nudiflora的枝叶中分离出来，这是一种治疗炎症相关疾病的中药。通过综合光谱分析和与报告数据的比较确定了它们的结构。生物测定结果显示，12 株分离物可明显抑制脂多糖 (LPS) 诱导的 RAW 264.7 细胞系中一氧化氮 (NO) 的产生，IC ₅₀值为 0.64 至 38.72 μM。其中，化合物1（3.27 μM）、6（5.23 μM）、13（1.56 μM）和14(0.64 μM) 表现出显着高于阳性对照 (27.13 μM) 的活性。此外，据推测环烯醚萜苷 C-4 位存在的羧基和类黄酮 C-3 位的糖基化可能会影响它们对 NO 产生的抑制活性。

更新日期：2022-11-14

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