Alternative splicing (AS) produces the different mRNA splicing bodies, which are then translated into multiple protein isoforms and participate in various biological functions. With a deeper understanding of alternative splicing through the study of transcriptomes using high-throughput sequencing-based methods, the correlation between aberrant AS and diseases triggered a great concern, especially abnormal AS and cancer. Medulloblastoma (MB) is an intracranial tumor in children. Sonic hedgehog MB (SHH-MB) accounted for approximately 30% of MB, which is associated with the activation of SHH signaling. Growing evidence shows that aberrant AS is closely related to the tumorigenesis of MB. Here, we briefly introduced the AS and its mechanism. Next, we described canonical/noncanonical hedgehog signaling and its correlation with MB. The main description focused on AS of various regulators in canonical hedgehog signaling in MB. In addition, we also described AS of various regulators in noncanonical hedgehog signaling. Meanwhile, activated hedgehog signaling also induces AS in MB. Then, we pointed out that aberrant AS of hedgehog signaling is associated with different MB subgroups. Finally, we summarized the therapeutic applications of targeted AS in cancer treatment. In summary, further understanding of AS in SHH-MB could develop therapeutic targets for splicing factors which may be a novel therapeutic strategy.

选择性剪接（AS）产生不同的mRNA剪接体，然后翻译成多种蛋白质亚型并参与各种生物学功能。通过使用基于高通量测序的方法对转录组进行研究，人们对选择性剪接有了更深入的了解，异常AS与疾病之间的相关性引起了人们的高度关注，特别是异常AS与癌症之间的关系。髓母细胞瘤（MB）是一种儿童颅内肿瘤。声波刺猬MB（SHH-MB）约占MB的30%，这与SHH信号的激活有关。越来越多的证据表明异常AS与MB的肿瘤发生密切相关。这里，我们简单介绍一下AS及其机制。接下来，我们描述了规范/非规范的刺猬信号传导及其与 MB 的相关性。主要描述集中于MB中规范hedgehog信号传导中的各种调节器的AS。此外，我们还描述了非规范hedgehog信号传导中各种调节器的AS。同时，激活的hedgehog信号传导也会诱导MB中的AS。然后，我们指出hedgehog信号的异常AS与不同的MB亚组相关。最后，我们总结了靶向AS在癌症治疗中的应用。总之，进一步了解 SHH-MB 中的 AS 可以开发剪接因子的治疗靶点，这可能是一种新的治疗策略。