The constrained disorder principle defines the existence and function of living organisms. The principle specifies that biological systems comprise a disorder within constrained random boundaries. Per this principle, living organisms are machines with a degree of error that do not strive to optimize. Their differentiator from non-living organisms is their intrinsic disorder within personalized dynamic random boundaries. The constrained disorder is mandatory for the systems' existence and proper operation. It provides living organisms the flexibility and adaptability required for operating under continuously changing internal and external milieus. The constrained disorder principle defines health and disease states by specifying the degree of the disorder and the arbitrary boundaries of biological systems. Disturbed systems lose their disorder or operate out of the disorder boundaries leading to diseases. The principle provides a platform for applying the constrained disorder to correct systems disturbances and improve disease outcomes.

受限无序原理定义了生物体的存在和功能。该原则指定生物系统包含受限随机边界内的无序。根据这一原则，生物体是具有一定程度误差且不会努力优化的机器。它们与非生物体的区别在于它们在个性化动态随机边界内的内在无序性。受限无序对于系统的存在和正常运行是强制性的。它为生物体提供了在不断变化的内部和外部环境下运行所需的灵活性和适应性。受限无序原则通过指定无序程度和生物系统的任意边界来定义健康和疾病状态。受干扰的系统会失去其紊乱状态或超出紊乱边界运行，从而导致疾病。该原理为应用约束障碍来纠正系统干扰和改善疾病结果提供了一个平台。