Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2022-11-10 , DOI: 10.1016/j.csbj.2022.11.013 E V Shikina 1, 2 , R A Kovalevsky 1 , A I Shirkovskaya 1 , Ph V Toukach 1, 3
|
The unique biological and rheological properties make hyaluronic acid a sought-after material for medicine and cosmetology. Due to very high purity requirements for hyaluronic acid in medical applications, the profitability of streptococcal fermentation is reduced. Production of hyaluronic acid by recombinant systems is considered a promising alternative. Variations in combinations of expressed genes and fermentation conditions alter the yield and molecular weight of produced hyaluronic acid. This review is devoted to the current state of hyaluronic acid production by recombinant bacterial and fungal organisms.
中文翻译：
透明质酸的前瞻性细菌和真菌来源：综述
独特的生物学和流变学特性使透明质酸成为医药和美容领域广受欢迎的材料。由于医疗应用对透明质酸的纯度要求非常高，因此链球菌发酵的盈利能力降低。通过重组系统生产透明质酸被认为是一种有前途的替代方法。表达基因组合和发酵条件的变化会改变所产生的透明质酸的产量和分子量。本综述致力于重组细菌和真菌生物体生产透明质酸的现状。
京公网安备 11010802027423号