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Copper halide mediated synthesis of mesoionic 6-halo-[1,2,3]triazolo[5,1-a]isoquinoliums: further transformation to polyheterocycles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-11-11 , DOI: 10.1039/d2qo01627c
Yangang Wu 1 , Wen Zhang 1 , Xiaolong Pan 1 , Chuanjun Song 1 , Junbiao Chang 1
Affiliation  

A highly efficient copper halide mediated oxidative cyclohalogenation approach toward mesoionic 6-halo-[1,2,3]triazo[5,1-a]isoquinoliums has been developed. The substrate scope is wide with broad functional group tolerance. In this transformation, concomitant C–N, C–O and C–X bond formation has been realized. Moreover, the products can be further transformed into other fused polyheterocyclic molecules.

中文翻译:

卤化铜介导的中间离子 6-卤代-[1,2,3]三唑并[5,1-a]异喹啉的合成:进一步转化为多杂环

已经开发了一种高效的卤化铜介导的氧化环卤化方法,用于制备中间离子 6-卤代-[1,2,3]三唑并[5,1- a ]异喹啉。底物范围广,官能团耐受性广。在这种转变中,已经实现了伴随的 C-N、C-O 和 C-X 键的形成。此外,产物还可以进一步转化为其他稠合多杂环分子。
更新日期:2022-11-14
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