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Multicompartment Nanoparticles by Crystallization-Driven Self-Assembly of Star Polymers: Combining High Stability and Loading Capacity
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2022-11-10 , DOI: 10.1002/marc.202200706 Haohui Huo 1 , Jing Zou 2 , Shu-Gui Yang 1 , Jiaqi Zhang 1 , Jie Liu 1 , Yutong Liu 2 , Yanyun Hao 2 , Hongfei Chen 2 , Hui Li 2 , Chaobo Huang 3 , Goran Ungar 1 , Feng Liu 1 , Zhiyue Zhang 2 , Qilu Zhang 1
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2022-11-10 , DOI: 10.1002/marc.202200706 Haohui Huo 1 , Jing Zou 2 , Shu-Gui Yang 1 , Jiaqi Zhang 1 , Jie Liu 1 , Yutong Liu 2 , Yanyun Hao 2 , Hongfei Chen 2 , Hui Li 2 , Chaobo Huang 3 , Goran Ungar 1 , Feng Liu 1 , Zhiyue Zhang 2 , Qilu Zhang 1
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Herein novel multicompartment nanoparticles (MCNs) that combine high stability and cargo loading capacity are developed. The MCNs are fabricated by crystallization-driven self-assembly (CDSA) of a tailor-made 21 arm star polymer, poly(L-lactide)[poly(tert-butyl acrylate)-block-poly(ethylene glycol)]20 [PLLA(PtBA-b-PEG)20]. Platelet-like or spherical MCNs containing a crystalline PLLA core and hydrophobic PtBA subdomains are formed and stabilized by PEG. Hydrophobic cargos, such as Nile Red and chemotherapeutic drug doxorubicin, can be successfully encapsulated into the collapsed PtBA subdomains with loading capacity two orders of magnitude higher than traditional CDSA nanoparticles. Depolarized fluorescence measurements of the Nile Red loaded MCNs suggest that the free volume of the hydrophobic chains in the nanoparticles may be the key for regulating their drug loading capacity. In vitro study of the MCNs suggests excellent cytocompatibility of the blank nanoparticles as well as a dose-dependent cellular uptake and cytotoxicity of the drug-loaded MCNs.
中文翻译：
星形聚合物结晶驱动自组装的多室纳米粒子：结合高稳定性和负载能力
在此开发了结合了高稳定性和载货能力的新型多隔室纳米颗粒 (MCN)。MCN 是通过定制的 21 臂星形聚合物、聚（L-丙交酯）[聚（丙烯酸叔丁酯）-嵌段-聚（乙二醇）]20 [PLLA] 的结晶驱动自组装( CDSA )制造的(P t BA- b -PEG) 20 ]。含有结晶 PLLA 核心和疏水性 P t BA 子域的类血小板或球形 MCN由 PEG 形成并稳定。疏水性货物，如尼罗红和化疗药物多柔比星，可以成功地封装到折叠的 P t中BA 子域的负载能力比传统的 CDSA 纳米粒子高两个数量级。载有尼罗红的 MCN 的去极化荧光测量表明，纳米颗粒中疏水链的自由体积可能是调节其载药能力的关键。MCN 的体外研究表明空白纳米粒子具有出色的细胞相容性，以及载药 MCN 的剂量依赖性细胞摄取和细胞毒性。
更新日期：2022-11-10
中文翻译：
星形聚合物结晶驱动自组装的多室纳米粒子：结合高稳定性和负载能力
在此开发了结合了高稳定性和载货能力的新型多隔室纳米颗粒 (MCN)。MCN 是通过定制的 21 臂星形聚合物、聚（L-丙交酯）[聚（丙烯酸叔丁酯）-嵌段-聚（乙二醇）]20 [PLLA] 的结晶驱动自组装( CDSA )制造的(P t BA- b -PEG) 20 ]。含有结晶 PLLA 核心和疏水性 P t BA 子域的类血小板或球形 MCN由 PEG 形成并稳定。疏水性货物，如尼罗红和化疗药物多柔比星，可以成功地封装到折叠的 P t中BA 子域的负载能力比传统的 CDSA 纳米粒子高两个数量级。载有尼罗红的 MCN 的去极化荧光测量表明，纳米颗粒中疏水链的自由体积可能是调节其载药能力的关键。MCN 的体外研究表明空白纳米粒子具有出色的细胞相容性，以及载药 MCN 的剂量依赖性细胞摄取和细胞毒性。
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