Evidence — provided by a combination of amyloid-β and tau PET examinations — of advanced Alzheimer’s disease pathological changes in the brain in cognitively unimpaired individuals is strongly associated with short-term (3–5 years) cognitive decline. Thus, amyloid-β and tau PET have high clinical relevance.

中文翻译：

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淀粉样蛋白-β 和 tau PET 扫描可预测认知未受损人群的临床进展

由淀粉样蛋白-β 和 tau PET 检查的组合提供的证据表明，认知未受损个体的晚期阿尔茨海默病大脑病理变化与短期（3-5 年）认知衰退密切相关。因此，淀粉样蛋白-β 和 tau PET 具有很高的临床相关性。