A tunable asymmetric strategy for the synthesis of sulfoglycolipids (SGLs) was developed. The strategy features a suite of asymmetrically protected trehaloses for acylation and sulfation. A practical synthetic route was explored for the preparation of polydeoxypropionate fatty acids, which together with the trehaloses enabled the synthesis of different classes of SGLs for immunological studies.

中文翻译：

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从结核分枝杆菌中不对称合成磺糖脂的可调策略，以阐明结构和免疫调节特性的关系

开发了一种用于合成磺基糖脂 (SGL) 的可调谐不对称策略。该策略具有一套用于酰化和硫酸化的不对称保护海藻糖。探索了一种实用的合成路线来制备聚脱氧丙酸脂肪酸，它与海藻糖一起能够合成不同类别的 SGL 用于免疫学研究。