Herein, we report an efficient and practical protocol for dehalocarboxylation of C(sp²)-halides with formate by the engagement of a CO₂ radical anion in a nickel-mediated bond-forming process. A wide variety of aryl iodides, aryl bromides, and alkenyl bromides bearing a diverse set of functional groups underwent the reaction smoothly through visible-light photoredox nickel dual catalysis. The synthesis of several ¹³C-labeled drug intermediates and the gram-scale synthesis of commercial drugs highlight the synthetic value of the approach in drug discovery settings.

中文翻译：

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双镍/光氧化还原催化 C(sp2)-卤化物与甲酸盐的羧化

在此，我们报告了一种有效且实用的方案，通过在镍介导的键形成过程中参与 CO _{2自由基阴离子，使 C(sp} ^{2 )-卤化物与甲酸盐脱卤羧化。}具有不同官能团的各种芳基碘化物、芳基溴化物和烯基溴化物通过可见光光氧化还原镍双催化顺利进行反应。几种¹³ C 标记的药物中间体的合成和商业药物的克级合成突出了该方法在药物发现环境中的合成价值。