Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2022-11-08 , DOI: 10.1007/s11418-022-01662-x Takefumi Kuranaga 1
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Peptidic natural products have received much attention as potential drug leads, and biosynthetic studies of peptidic natural products have contributed to the field of natural product chemistry over the past several decades. However, the key biosynthetic intermediates are generally not isolated from natural sources, and this can hamper a detailed analysis of biosynthesis. Furthermore, reported unusual structures, which are targets for biosynthetic studies, are sometimes the results of structural misassignments. Chemical synthesis techniques are imperative in solving these problems. This review focuses on the chemical syntheses of surugamides and thioamycolamides toward understanding their biosynthesis. These studies can provide the key biosynthetic intermediates that can reveal the biosynthetic pathways and/or true structures of these natural products.
Graphical abstract
中文翻译：
蔗糖酰胺和硫代酰胺的全合成，以了解其生物合成
肽类天然产物作为潜在的药物先导物受到了广泛的关注，在过去的几十年里，肽类天然产物的生物合成研究为天然产物化学领域做出了贡献。然而，关键的生物合成中间体通常不是从天然来源中分离出来的，这可能会妨碍生物合成的详细分析。此外，报道的异常结构（生物合成研究的目标）有时是结构错误分配的结果。化学合成技术对于解决这些问题势在必行。本综述重点关注蔗糖酰胺和硫代酰胺的化学合成，以了解它们的生物合成。这些研究可以提供关键的生物合成中间体，从而揭示这些天然产物的生物合成途径和/或真实结构。
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