Isolation, Structure Characterization, Total Synthesis and Biological Evaluation of Cinnamic Acid Derivatives from Tinospora sagittata,Chemistry & Biodiversity

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Isolation, Structure Characterization, Total Synthesis and Biological Evaluation of Cinnamic Acid Derivatives from Tinospora sagittata
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-08 , DOI: 10.1002/cbdv.202200942
De-Feng Xu ₁ , Pei-Wen Su ₁ , Chao Wang ₁ , Lei Miao ₁ , Jun-Sheng Zhang ₁ , Hua Zhang ₁

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Thirteen cinnamic acid derivatives (1–13), including six formerly unreported hybrids incorporating different short-chain fatty acid esters (1–6), have been obtained and structurally elucidated from an ethnological herb Tinospora sagittata. The structures of them have been established by spectroscopic data analyses and NMR comparison with known analogs, while those of 1, 2, 4 and 6 have been further supported by total synthesis, and it is the first report of this type of metabolites from the title species. All the isolates have been assessed in an array of bioassays encompassing cytotoxic, antibacterial, anti-inflammatory, antioxidant, as well as α-glucosidase and HDAC1 inhibitory models. Compound 7 showed significant inhibitory activity against α-glucosidase, and half of the isolates also displayed moderate antiradical effect.

中文翻译：

箭形牛胆肉桂酸衍生物的分离、结构表征、全合成及生物学评价

十三种肉桂酸衍生物 ( 1 – 13 )，包括六种以前未报道的包含不同短链脂肪酸酯的杂化物 ( 1 – 6 )，已从一种民族学草药Tinospora sagittata中获得并在结构上进行了阐明。它们的结构已通过光谱数据分析和核磁共振与已知类似物的比较确定，而1、2、4和6得到了全合成的进一步支持，这是标题物种中此类代谢物的首次报道。所有分离株都在一系列生物测定中进行了评估，包括细胞毒性、抗菌、抗炎、抗氧化以及 α-葡萄糖苷酶和 HDAC1 抑制模型。化合物7对 α-葡萄糖苷酶显示出显着的抑制活性，并且一半的分离物还显示出中等的抗自由基作用。

更新日期：2022-11-08

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