Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds,Organic Chemistry Frontiers

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Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-11-08 , DOI: 10.1039/d2qo01582j
Praveen P. Singh ₁ , Pravin K. Singh ₂ , Vishal Srivastava ₂

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The late stage functionalization (LSF) of complex biorelevant chemicals is a valuable approach for accelerating the discovery of structure–activity relationships (SARs) and optimising ADME (absorption, distribution, metabolism, and excretion) profiles. To this end, visible-light metallaphotocatalysis provides a unique opportunity to develop smooth and clean drug functionalization by realising site-specific reactivities under very mild reaction conditions. This study provides a comprehensive evaluation of the current research, highlighting recent advances in the discipline while emphasising predicted future advancements and prospective applications along with visible-light metallaphotocatalytic synthesis methods for the LSF of medicines and pharmaceutically potent compounds that are now accessible.

中文翻译：

可见光金属光氧化还原催化药用化合物的后期功能化

复杂生物相关化学品的后期功能化 (LSF) 是加速发现构效关系 (SAR) 和优化 ADME（吸收、分布、代谢和排泄）概况的宝贵方法。为此，可见光金属光催化通过在非常温和的反应条件下实现位点特异性反应，提供了一个独特的机会来开发平稳和清洁的药物功能化。本研究对当前研究进行了全面评估，重点介绍了该学科的最新进展，同时强调了预测的未来进展和前瞻性应用，以及用于药物和药物有效化合物 LSF 的可见光金属光催化合成方法。

更新日期：2022-11-08

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