Atropisomeric compounds are found extensively as natural products, as ligands for asymmetric transition-metal catalysis, and increasingly as bioactive and pharmaceutically relevant targets. Their enantioselective synthesis is therefore an important ongoing research target. While a vast majority of known atropisomeric structures are (hetero)biaryls, which display hindered rotation around a C–C single bond, our group’s long-standing interest in the control of molecular conformation has led to the identification and stereoselective preparation of a variety of other classes of “nonbiaryl” atropisomeric compounds displaying restricted rotation around C–C, C–N, C–O, and C–S single bonds.

中文翻译：

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阻转异构体的生物催化对映选择性合成

阻转异构化合物作为天然产物广泛存在，作为不对称过渡金属催化的配体，并且越来越多地作为生物活性和药学相关靶标。因此，它们的对映选择性合成是一个重要的持续研究目标。虽然绝大多数已知的阻转异构结构是（杂）联芳基，它们显示出围绕 C-C 单键的受阻旋转，但我们小组对分子构象控制的长期兴趣导致了各种鉴定和立体选择性制备其他类别的“非联芳基”阻转异构化合物显示出围绕 C-C、C-N、C-O 和 C-S 单键的受限旋转。