Dithiol-Activated Bioorthogonal Chemistry for Endoplasmic Reticulum-Targeted Synergistic Chemophototherapy,Angewandte Chemie International Edition

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Dithiol-Activated Bioorthogonal Chemistry for Endoplasmic Reticulum-Targeted Synergistic Chemophototherapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-07 , DOI: 10.1002/anie.202213765
Jian Sun _{1,

2} , Xiaoran Zhang ₂ , Xia Wang ₂ , Jinlei Peng ₂ , Gang Song _{1,

3} , Yufei Di _{1,

3} , Fude Feng ₂ , Shu Wang _{1,

3}

Affiliation

Bioorthogonal chemistry is introduced for design of organic nitrite donors, on the basis of S_NAr and cyclization reactions between dithiols and 5-nitrobenzo[c][2,1,3]thiadiazole derivatives. A combination of “click to release” strategy and photoactivation is achievable for cancer chemophototherapy.

中文翻译：