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Preparation and Characterization of Polysaccharides from Turpiniae Folium and Its Antioxidative, Anti-Inflammatory Activities and Antiproliferative Effect on VSMCs
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-03 , DOI: 10.1002/cbdv.202200459 Jing Yan 1, 2 , Ling-Jia Zhao 1 , Ya-Mei Li 1 , Zhi-Min Zhang 1 , Li-Mei Lin 1 , Bo-Hou Xia 1
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-03 , DOI: 10.1002/cbdv.202200459 Jing Yan 1, 2 , Ling-Jia Zhao 1 , Ya-Mei Li 1 , Zhi-Min Zhang 1 , Li-Mei Lin 1 , Bo-Hou Xia 1
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Turpiniae Folium, the dried leaves of Turpinia arguta Seem., is a kind of historic traditional Chinese medicine. Here, based on our previous study, we extracted the Turpiniae Folium polysaccharides (TFP) and isolated three polysaccharide fractions from TFP. Then, TFP and one of the major polysaccharide fractions (TFP-1a) were identified through HPLC, HPGPC, and ATR-FTIR. Furthermore, the evaluations of their antioxidative, anti-inflammatory activities and inhibitory effect on angiotensin II-induced vascular smooth muscle cells (VSCMs) proliferation in vitro were conducted. Both TFP and TFP-1a showed strong hydroxyl radical scavenging, DPPH radical scavenging, and Fe2+ chelating activities, and exerted strong anti-inflammatory activity. Moreover, TFP and TFP-1a also possessed a strong inhibitory effect on Ang II-induced VSCMs proliferation. On these premises, we inferred that TFP and TFP-1a could be potential and promising natural antioxidants, anti-inflammatory agents, and implicated to treat cardiovascular disease.
中文翻译：
油桐叶多糖的制备、表征及其抗氧化、抗炎和抗 VSMC 增殖作用
Turpiniae Folium，Turpinia arguta Seem. 的干燥叶，是一种历史悠久的中药。在这里，根据我们之前的研究，我们提取了Turpiniae Folium多糖 (TFP) 并从 TFP 中分离出三种多糖组分。然后，通过 HPLC、HPGPC 和 ATR-FTIR 鉴定了 TFP 和一种主要多糖组分 (TFP-1a)。此外，还评估了它们的抗氧化、抗炎活性和对血管紧张素 II 诱导的血管平滑肌细胞 (VSCM)体外增殖的抑制作用。TFP 和 TFP-1a 均表现出很强的羟基自由基清除、DPPH 自由基清除和 Fe 2+螯合活性，并发挥强烈的抗炎活性。此外，TFP 和 TFP-1a 对 Ang II 诱导的 VSCMs 增殖也具有强烈的抑制作用。在这些前提下，我们推断 TFP 和 TFP-1a 可能是潜在且有前途的天然抗氧化剂、抗炎剂，并与治疗心血管疾病有关。
更新日期：2022-11-03
中文翻译：
油桐叶多糖的制备、表征及其抗氧化、抗炎和抗 VSMC 增殖作用
Turpiniae Folium，Turpinia arguta Seem. 的干燥叶，是一种历史悠久的中药。在这里，根据我们之前的研究，我们提取了Turpiniae Folium多糖 (TFP) 并从 TFP 中分离出三种多糖组分。然后，通过 HPLC、HPGPC 和 ATR-FTIR 鉴定了 TFP 和一种主要多糖组分 (TFP-1a)。此外，还评估了它们的抗氧化、抗炎活性和对血管紧张素 II 诱导的血管平滑肌细胞 (VSCM)体外增殖的抑制作用。TFP 和 TFP-1a 均表现出很强的羟基自由基清除、DPPH 自由基清除和 Fe 2+螯合活性，并发挥强烈的抗炎活性。此外，TFP 和 TFP-1a 对 Ang II 诱导的 VSCMs 增殖也具有强烈的抑制作用。在这些前提下，我们推断 TFP 和 TFP-1a 可能是潜在且有前途的天然抗氧化剂、抗炎剂，并与治疗心血管疾病有关。
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