当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Imine Directed Cp*RhIII-Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-04 , DOI: 10.1002/anie.202210822
Adam J Zoll 1 , Jenna C Molas 1 , Brandon Q Mercado 1 , Jonathan A Ellman 1
Affiliation  

A multicomponent, imine directed Cp*RhIII-catalyzed N−H functionalization/annulation is reported. This method represents the first example of multicomponent N−H functionalization and allows for rapid access to a heterocyclic product. Further transformations and a plausible mechanism based on X-ray crystallographic characterization of a catalytically competent rhodacycle intermediate are disclosed.

中文翻译:


亚胺导向的 Cp*RhIII 催化 NH 官能化和氨基酰胺、醛和重氮化合物的环化



报道了一种多组分、亚胺定向的 Cp*Rh III催化的 NH 官能化/环化。该方法代表了多组分 NH 官能化的第一个例子,并允许快速获得杂环产物。公开了基于具有催化活性的铑环中间体的 X 射线晶体学表征的进一步转化和合理机制。
更新日期:2022-11-04
down
wechat
bug