Imine Directed Cp*RhIII-Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds,Angewandte Chemie International Edition

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Imine Directed Cp*RhIII-Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-04 , DOI: 10.1002/anie.202210822
Adam J Zoll ₁ , Jenna C Molas ₁ , Brandon Q Mercado ₁ , Jonathan A Ellman ₁

Affiliation

A multicomponent, imine directed Cp*Rh^III-catalyzed N−H functionalization/annulation is reported. This method represents the first example of multicomponent N−H functionalization and allows for rapid access to a heterocyclic product. Further transformations and a plausible mechanism based on X-ray crystallographic characterization of a catalytically competent rhodacycle intermediate are disclosed.

中文翻译：

亚胺导向的 Cp*RhIII 催化 NH 官能化和氨基酰胺、醛和重氮化合物的环化

报道了一种多组分、亚胺定向的 Cp*Rh ^III催化的 NH 官能化/环化。该方法代表了多组分 NH 官能化的第一个例子，并允许快速获得杂环产物。公开了基于具有催化活性的铑环中间体的 X 射线晶体学表征的进一步转化和合理机制。

更新日期：2022-11-04

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