Rhodium-Catalyzed Dynamic Kinetic Asymmetric Hydrosilylation to Access Silicon-Stereogenic Center,Angewandte Chemie International Edition

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Rhodium-Catalyzed Dynamic Kinetic Asymmetric Hydrosilylation to Access Silicon-Stereogenic Center
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-11-03 , DOI: 10.1002/anie.202214147
Yan Zeng ₁ , Xiao-Jun Fang ₁ , Ren-He Tang ₁ , Jing-Yu Xie ₁ , Feng-Jiao Zhang ₁ , Zheng Xu ₁ , Yi-Xue Nie ₁ , Li-Wen Xu ₁

Affiliation

An unprecedented (SiMOS-Phos) ligand-controlled Rh-catalyzed hydrosilylation of “silicon-centered” racemic hydrosilanes was developed for the highly efficient and enantioselective construction of silicon-stereogenic centers of benzosiloles (up to 96 : 4 er). This achievement was obtained by using an original synthetic strategy involving dynamic kinetic asymmetric transformations.

中文翻译：

铑催化的动态动力学不对称氢化硅烷化反应进入硅立构中心

开发了一种前所未有的 (SiMOS-Phos) 配体控制的 Rh 催化的“以硅为中心”的外消旋氢硅烷的氢化硅烷化反应，用于高效和对映选择性地构建苯并硅烷的硅立体异构中心（高达 96：4 er）。这一成就是通过使用涉及动态动力学不对称变换的原始合成策略获得的。

更新日期：2022-11-03

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