A biocatalytic thionation method is presented for the enantioselective synthesis of thiiranes from epoxides by a halohydrin dehalogenase catalyzed kinetic resolution approach using thiocyanate as a sulfur donor. Various chiral thiiranes bearing aryl and alkyl substituents were synthesized in good yields and enantioselectivities by using recombinant Escherichia coli cells expressing the engineered halohydrin dehalogenase HHDHapb variants.

中文翻译：

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环氧化物的生物催化硫磺化对映选择性合成硫杂环丙烷

提出了一种生物催化硫代化方法，用于使用硫氰酸盐作为硫供体，通过卤代醇脱卤酶催化的动力学拆分方法，从环氧化物中对映选择性合成硫杂环丙烷。通过使用表达工程化卤代醇脱卤素酶 HHDHapb 变体的重组大肠杆菌细胞，以良好的产率和对映体选择性合成了带有芳基和烷基取代基的各种手性硫杂环丙烷。