Sesquiterpenoids Isolated from the Rhizomes of Genus Atractylodes,Chemistry & Biodiversity

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Sesquiterpenoids Isolated from the Rhizomes of Genus Atractylodes
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-02 , DOI: 10.1002/cbdv.202200703
Han-Young Kim ₁ , Jung-Hoon Kim ₂

Affiliation

Atractylodes plants have been used in traditional herbal medicine to treat gastrointestinal diseases and contain various chemical compounds. Sesquiterpenoids are the most important therapeutic compounds in Atractylodes rhizomes. Based on studies reported from 2000 to 2022, we classified sesquiterpenoids by their chemical skeletons and original resources. Moreover, we discussed their biosynthesis and physicochemical and pharmacological features. We reported sesquiterpenoids with skeletal moieties, such as monocyclic sesquiterpenes (bisabolene- and elemene-type), bicyclic sesquiterpenes (eudesmane-, isopterocarpolone-, hydroxycarissone-, eremophilane-, bisesquiterpenoid-, guaiane- and spirovetivane-type and eudesmane lactones) and tricyclic sesquiterpenes (cyperene- and patchoulene-type), with their biosynthetic pathways, chemical modifications and in vivo metabolites. The pharmacological activities of sesquiterpenoids as anti-inflammatory, anti-tumor, anti-diabetic and anti-microbial and for treating gastrointestinal disorders have been reported for this genus.

中文翻译：

从白术属植物根茎中分离得到的倍半萜类化合物

白术植物已被用于传统草药治疗胃肠道疾病，并含有多种化合物。倍半萜类化合物是白术中最重要的治疗化合物根茎。根据 2000 年至 2022 年报告的研究，我们根据化学骨架和原始资源对倍半萜类化合物进行了分类。此外，我们还讨论了它们的生物合成以及理化和药理学特征。我们报道了具有骨架部分的倍半萜类化合物，例如单环倍半萜烯（红没药烯和榄香烯型）、双环倍半萜烯（eudesmane-、isopterocarpolone-、hydroxycarissone-、eremophilane-、双倍半萜类、愈创木醚和spirovetivane-型和eudesmane内酯）和三环倍半萜烯（cyperene 和 patchoulene 型）及其生物合成途径、化学修饰和体内研究代谢物。已经报道了倍半萜类化合物的药理活性，如抗炎、抗肿瘤、抗糖尿病和抗微生物以及治疗胃肠道疾病。

更新日期：2022-11-02

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