Scarring is caused by excessive medical treatment in the tissue remodeling stage; hence, the need for medication is not constant throughout the stage of burn recovery. In this study, we construct a nano self-adaption release system (Cur-ZIF8-HA) using hyaluronic acid (HA)-modified zeolite-imidazole-frame-8 (ZIF-8) as the nano-vehicle and curcumin (Cur) as the bioactive compound for the treatment of burns. The release of Cur within 48 h in the media of pH 8.5, pH 6.0, and pH 7.4 was 13.94, 54.05, and 20.17%, which could realize antibacterial functions in the inflammation stage, wound healing in the tissue proliferation/formation stage, and prevention of excessive fibroblast development and aberrant extracellular matrix deposition in the remodeling stage. Based on this property, Cur-ZIF8-HA has superior efficacy in healing bacterially infected burn wounds in vivo. This work provides a self-adaption release system with antibacterial wound-healing properties and prevents scarring functional based on the ZIF8-HA nano-vehicle, which opens a new way for the clinical application of curcumin for burn healing.

中文翻译：

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透明质酸修饰的 ZIF-8 纳米载体用于自适应释放姜黄素治疗烧伤

瘢痕形成是组织重塑阶段过度药物治疗所致；因此，在烧伤恢复的整个阶段，对药物的需求并不是恒定不变的。在这项研究中，我们使用透明质酸 (HA)-改性沸石-咪唑-框架-8 (ZIF-8) 作为纳米载体和姜黄素 (Cur) 构建了纳米自适应释放系统 (Cur-ZIF8-HA)作为治疗烧伤的生物活性化合物。Cur在pH 8.5、pH 6.0和pH 7.4介质中48 h的释放量分别为13.94、54.05和20.17%，可实现炎症阶段的抗菌作用，组织增殖/形成阶段的伤口愈合，以及预防重塑阶段成纤维细胞过度发育和细胞外基质异常沉积。基于这个属性，体内。该工作基于ZIF8-HA纳米载体提供了一种具有抗菌创面愈合和防止瘢痕形成功能的自适应释放系统，为姜黄素用于烧伤愈合的临床应用开辟了一条新途径。