Partial Retraction of: The EMBO Journal (2010) 29: 3607–3620. DOI: 10.1038/emboj.2010.237 | Published online 24 September 2010 Journal statement The journal contacted the authors in February 2022 about potential image insertions and duplications in Fig 4A and 4E. In the absence of source data, the authors are retracting Fig 4A, the lower panel of Fig 4E (LAMP1 immunoblot), and the following statements in the text that rely on these data: “Quantitative analysis showed that the percentage of Flotillin-1 associated with DRMs was increased in LSD endolysosomal membranes (Figure 4A), indicating an increased amount of cholesterol-enriched regions in these membrane samples.” “LAMP1 also displayed a similar distribution profile in WT and LSD cells (Figure 4E)”. Author statement The authors could not verify the aberrations in panel A of Fig 4 and the lower immunoblot (LAMP1) of 4E because the original source data are no longer available (12 years after publication, which is beyond the institute's 10-year data retention policy). The authors wish to clarify that the main conclusions of the paper are not affected by the retraction of Figure panels 4A and 4E for the following reasons: The authors apologize for these errors and agree with this corrigendum; no response could be obtained from AL.

中文翻译：

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溶酶体贮积症中的胆固醇积累会损害溶酶体融合和 SNARE 功能

部分撤回： EMBO 期刊(2010) 29：3607–3620。DOI：10.1038/emboj.2010.237 | 2010 年 9 月 24 日在线发布期刊声明该期刊于 2022 年 2 月就图 4A 和 4E 中可能的图像插入和重复联系了作者。在没有源数据的情况下，作者撤回了图 4A、图 4E 的下图（LAMP1 免疫印迹）以及文本中依赖于这些数据的以下陈述：“定量分析表明，与 Flotillin-1 相关的百分比DRMs 在 LSD 内溶酶体膜中增加（图 4A），表明这些膜样本中富含胆固醇的区域数量增加。” “LAMP1 在 WT 和 LSD 细胞中也表现出相似的分布特征（图 4E）”。作者声明作者无法验证图 4 的面板 A 和 4E 的较低免疫印迹 (LAMP1) 中的畸变，因为原始源数据不再可用（出版后 12 年，这超出了研究所的 10 年数据保留政策）。作者希望澄清，本文的主要结论不受图面板 4A 和 4E 撤回的影响，原因如下：作者为这些错误道歉并同意本勘误；无法从 AL 获得任何回应。