Investigation of particle manipulation mechanism and size sorting strategy in a double-layered microchannel,Lab on a Chip

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Investigation of particle manipulation mechanism and size sorting strategy in a double-layered microchannel
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-11-02 , DOI: 10.1039/d2lc00822j
Zhang Boran _{1,

2} , Yang Fan ₃ , Wu Wenshuai ₄ , Wan Wuyi ₂ , Zhao Wenhan ₁ , Zhao Qianbin ₅

Affiliation

Traditionally, comprehensive laboratorial experiments on newly proposed microfluidic devices are necessary for theoretical validation, technological design, methodological calibration and optimization. Multiple parameters and characteristics, such as the flow rate, particle size, microchannel dimensions, etc., should be studied by controlled trials, which could inevitably result in extensive experiments and a heavy burden on researchers. In this work, a novel numerical model was introduced to simulate particle migration within a complicated double-layered microchannel. Using the hybrid meshing method, the proposed model achieved a significant improvement in meshing quality, and remarkably reduced the required calculation resources at the same time. The robust, efficient and resource-saving numerical model was calibrated and validated with experimental results. Based on this model, 1) the mechanism of microparticle manipulation within the microchannel was revealed; 2) the primary reason for the microparticle focusing failure was investigated; and 3) the optimal microparticle sorting strategy at different flow rates was analyzed. In experiments, the obtained optimal strategy could approach a good sorting performance with a high recovery rate and high concentration ratio in a high-throughput manner. The proposed numerical model shows great potential in mechanism investigation and functional prediction for microfluidic technologies using unconventional designs.

中文翻译：

双层微通道中颗粒操纵机制和尺寸分选策略研究

传统上，理论验证、技术设计、方法校准和优化需要对新提出的微流体装置进行综合实验室实验。多种参数和特性，如流速、粒径、微通道尺寸等。, 应该通过对照试验来研究，这不可避免地导致大量的实验和沉重的研究人员负担。在这项工作中，引入了一种新颖的数值模型来模拟复杂双层微通道内的粒子迁移。使用混合网格划分方法，所提出的模型在网格划分质量上取得了显着改善，同时显着减少了所需的计算资源。稳健、高效和节省资源的数值模型通过实验结果进行了校准和验证。基于该模型，1）揭示了微通道内微粒操纵的机制；2）调查了微粒聚焦失败的主要原因；3）分析了不同流速下的最佳微粒分选策略。在实验中，所获得的最优策略可以以高通量的方式接近具有高回收率和高浓缩比的良好分选性能。所提出的数值模型在使用非常规设计的微流体技术的机制研究和功能预测方面显示出巨大潜力。

更新日期：2022-11-02

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