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Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti-Inflammatory Activities
Chemistry & Biodiversity ( IF 2.9 ) Pub Date : 2022-11-01 , DOI: 10.1002/cbdv.202200870
Yang Xu 1 , Huiru Xie 1 , Hongbo Chen 1 , Liangliang Xiong 1 , Kuiru Sa 1 , Xuanbin Wang 2 , Hua Li 1, 3 , Lixia Chen 1
Affiliation  

A new triterpenoid, 3β-hydroxyurs-12-en-28,20β-olide (1), as well as thirteen known terpenoids (214) and three known phenylpropanoids (1517), were isolated from the twigs and leaves of Abelia macrotera. Compounds 2, 517 were isolated for the first time from the Abelia genus. The structure of compound 1 was determined using the characteristic spectral data (HR-ESI-MS, UV, 1D and 2D-NMR, and X-ray single-crystal diffraction. Furthermore, the inhibitory effects of all compounds on NO production in LPS-induced RAW 264.7 cells were tested, and compound 15 showed obvious inhibitory effect, with IC50 values of 23.77±1.61 μM. Through target screening and molecular docking technology, it can be speculated that compound 15 may play an anti-inflammatory role by combining with Cathepsin G & Chymase and HPG D.

中文翻译:

从 Abelia macrotera 的枝叶中分离的萜类化合物和苯丙烷类化合物及其抗炎活性

从树枝和_ _ _ _ _ _ _ _ _ _ _ _ Abelia macrotera的叶子。化合物2 , 5 ~ 17为首次从木香属植物中分离得到。化合物1的结构使用特征光谱数据(HR-ESI-MS、UV、1D 和 2D-​​NMR,以及 X 射线单晶衍射)确定。此外,所有化合物对 LPS 诱导的 RAW 264.7 细胞中 NO 产生的抑制作用是经测试,化合物15表现出明显的抑制作用,IC 50值为23.77±1.61 μM。通过靶点筛选和分子对接技术,可以推测化合物15可能通过与Cathepsin G & Chymase联合发挥抗炎作用, HPG D。
更新日期:2022-11-01
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