Aspartate Alleviates Colonic Epithelial Damage by Regulating Intestinal Stem Cell Proliferation and Differentiation via Mitochondrial Dynamics,Molecular Nutrition & Food Research

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Aspartate Alleviates Colonic Epithelial Damage by Regulating Intestinal Stem Cell Proliferation and Differentiation via Mitochondrial Dynamics
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-10-30 , DOI: 10.1002/mnfr.202200168
Dan Wang ₁ , Yanling Kuang ₁ , Zhicheng Wan ₁ , Pei Li ₁ , Jiangchao Zhao ₂ , Huiling Zhu ₁ , Yulan Liu ₁

Affiliation

Proliferation and differentiation of intestinal stem cells (ISCs) are crucial for functional restoration after injury, which can be regulated by nutritional molecules. Aspartate is implicated in maintaining intestinal barrier after injury, but underlying mechanisms remain elusive. Here, this study seeks to investigate if aspartate alleviates colonic epithelial damage by regulating ISC function, and to elucidate its mechanisms.

中文翻译：

天冬氨酸通过线粒体动力学调节肠干细胞增殖和分化减轻结肠上皮损伤

肠道干细胞 (ISC) 的增殖和分化对于损伤后的功能恢复至关重要，这可以通过营养分子进行调节。天冬氨酸与损伤后肠道屏障的维持有关，但其潜在机制仍不清楚。在这里，本研究旨在调查天冬氨酸是否通过调节 ISC 功能减轻结肠上皮损伤，并阐明其机制。

更新日期：2022-10-30

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