当前位置: X-MOL 学术Org. Chem. Front. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Copper-catalyzed aerobic nitrogen-migration cyanation and oxygenation of unsaturated ketoximes via the CC bond cleavage: facile access to 4-oxobutanenitriles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-10-29 , DOI: 10.1039/d2qo01553f
Xiao-Dong Liu 1, 2 , Yang Li 2 , Ming Hu 1, 2 , Qiu-An Wang 1 , Jin-Heng Li 1, 2, 3, 4
Affiliation  

A new copper-catalyzed aerobic synthesis of 4-oxobutanenitriles by the nitrogen-migration cyanation and oxygenation of γ,δ-unsaturated ketoximes at room temperature is developed. By means of a copper(0) powder catalyst, the nitrogen-migration cyanation and oxygenation of unsaturated ketoximes with O2 via a radical intramolecular 5-exo-trig cyclization, C[double bond, length as m-dash]C double bond cleavage and ring-opening process efficiently execute to assemble 4-oxobutanenitriles. Mechanistic studies indicate that these processes include radicals initiating the reaction from the oxime side and the superoxide radical formation.

中文翻译:

铜催化的好氧氮迁移氰化和不饱和酮肟通过CC键断裂的氧化:容易获得4-氧代丁腈

通过氮迁移氰化和γ,δ-不饱和酮肟在室温下的氧合,开发了一种新的铜催化好氧合成4-氧代丁腈。借助铜(0)粉末催化剂,不饱和酮肟与O 2 通过自由基分子内5-外-三环化、C - [双键,长度为 m-dash]C双键断裂和开环过程有效地进行氮迁移氰化和氧化以组装4 -氧代丁腈。机理研究表明,这些过程包括从肟侧引发反应的自由基和超氧自由基的形成。
更新日期:2022-10-29
down
wechat
bug