Consecutive 2-azidoallylation/click cycloaddition of active methylene for synthesis of functionalized hepta-1,6-dienes with a bis-1,2,3-triazole scaffold,Organic Chemistry Frontiers

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Consecutive 2-azidoallylation/click cycloaddition of active methylene for synthesis of functionalized hepta-1,6-dienes with a bis-1,2,3-triazole scaffold
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-10-28 , DOI: 10.1039/d2qo01118b
Zhenhua Liu ₁ , Huimin Chen ₁ , Xingxing Gan ₁ , Lianxiao Wang ₂ , Ping Lin ₁ , Jiayi Li ₁ , Xiuxiu Huang ₁ , Rongbiao Tian ₁ , Xuan Liu ₁ , Wen Gao ₁ , Bo Tang ₁

Affiliation

A tandem 2-azidoallylation/click cycloaddition reaction can be accomplished with methylene compounds, phenolic substituted vinyl azide and alkynes in one pot. This general cascade reaction smoothly enables the construction of novel multifunctional hepta-1,6-dienes bearing quaternary/tertiary carbon and a bis-1,2,3-triazole scaffold in good to excellent yields.

中文翻译：

活性亚甲基的连续 2-叠氮烯丙基化/点击环加成用于合成具有双 1,2,3-三唑支架的功能化 1,6-二烯

可以用亚甲基化合物、酚取代的乙烯基叠氮化物和炔烃在一锅中完成串联的 2-叠氮烯丙基化/点击环加成反应。这种通用级联反应能够顺利地构建具有季/叔碳的新型多功能庚-1,6-二烯和双-1,2,3-三唑支架，产率良好。

更新日期：2022-10-28

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