Herein, we describe the first total synthesis of (+)-ent-vetiverianine A, which exhibits a 5/6/6-fused tricyclic structure. The key reactions, including Lewis acid-mediated cyclization, Mukaiyama hydration, enantioselective Shi epoxidation, Birch reduction, and other effective transformations, enabled enantioselective access to (+)-ent-vetiverianine A with the longest linear sequence of 14 steps, and in 12% overall yield.

中文翻译：

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(+)-ent-vetiverianine a 通过路易斯酸介导的环化全合成

在此，我们描述了 (+)- ent -vetiverianine A 的首次全合成，其表现出 5/6/6-稠合三环结构。关键反应，包括路易斯酸介导的环化、Mukaiyama 水合、对映选择性 Shi 环氧化、Birch 还原和其他有效转化，使对映选择性获得 (+)- ent -vetiverianine A 具有最长的 14 步线性序列，并且在 12 % 总产率。