Recent developments in enantioselective nickel(II)-catalyzed conjugate additions,Organic Chemistry Frontiers

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Recent developments in enantioselective nickel(II)-catalyzed conjugate additions
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-10-24 , DOI: 10.1039/d2qo01047j
Hélène Pellissier ₁

Affiliation

This review highlights the recent developments in enantioselective nickel-catalyzed conjugate additions of various nucleophiles to numerous acceptor-activated olefins published since 2016. By the very fact of the lower costs of nickel catalysts in comparison with other transition metals, these reactions represent powerful and economic methodologies for the stereocontrolled formation of carbon–carbon and carbon-heteroatom bonds. When applied to initiate domino reactions, these processes allowed a direct access to a variety of complex and functionalized chiral molecules.

中文翻译：

对映选择性镍 (II) 催化共轭添加的最新进展

这篇综述重点介绍了自 2016 年以来发表的各种亲核试剂的对映选择性镍催化共轭加成到众多受体活化烯烃中的最新进展。与其他过渡金属相比，镍催化剂的成本较低，这些反应代表了强大和经济碳 - 碳和碳 - 杂原子键的立体控制形成方法。当应用于引发多米诺骨牌反应时，这些过程允许直接访问各种复杂和功能化的手性分子。

更新日期：2022-10-27

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