Imaging and Editing the Phospholipidome,Accounts of Chemical Research

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Imaging and Editing the Phospholipidome
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2022-10-24 , DOI: 10.1021/acs.accounts.2c00510
Din-Chi Chiu _{1,

2} , Jeremy M Baskin _{1,

2}

Affiliation

Membranes are multifunctional supramolecular assemblies that encapsulate our cells and the organelles within them. Glycerophospholipids are the most abundant component of membranes. They make up the majority of the lipid bilayer and play both structural and functional roles. Each organelle has a different phospholipid composition critical for its function that results from dynamic interplay and regulation of numerous lipid-metabolizing enzymes and lipid transporters. Because lipid structures and localizations are not directly genetically encoded, chemistry has much to offer to the world of lipid biology in the form of precision tools for visualizing lipid localization and abundance, manipulating lipid composition, and in general decoding the functions of lipids in cells.

中文翻译：

磷脂组成像和编辑

膜是多功能超分子组件，将我们的细胞及其内的细胞器封装起来。甘油磷脂是膜中最丰富的成分。它们构成了脂质双层的大部分，并发挥结构和功能作用。每个细胞器都有不同的磷脂成分，对其功能至关重要，这是由众多脂质代谢酶和脂质转运蛋白的动态相互作用和调节产生的。由于脂质结构和定位不是直接由基因编码的，化学可以以精密工具的形式为脂质生物学领域提供很多帮助，用于可视化脂质定位和丰度、操纵脂质组成以及总体上解码细胞中脂质的功能。

更新日期：2022-10-24

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