Prumnopitys Andina Fruit Extract Activates Liver X Receptors after In Vitro Digestion,Molecular Nutrition & Food Research

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Prumnopitys Andina Fruit Extract Activates Liver X Receptors after In Vitro Digestion
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-10-20 , DOI: 10.1002/mnfr.202200377
Felipe Jiménez-Aspee ₁ , Jonas Pospiech ₁ , Sarah Bauer ₂ , Nadine Sus ₁ , Thomas A Kufer ₂ , Jan Frank ₁

Affiliation

20-Hydroxyecdysone (20E) is the main phytochemical present in the fresh arils of Prumnopitys andina. 20E is reported to have anabolic effects by modulation of gene transcription by interaction with nuclear receptors. Our aim is to evaluate the in vitro bioaccessibility, transepithelial transport of 20E, and the capacity of P. andina fruit extract and 20E to activate selected mammalian nuclear receptors in transiently transfected human cells after simulated gastrointestinal digestion.

中文翻译：

安地那果实提取物在体外消化后激活肝脏 X 受体

20-羟基蜕皮激素 (20E) 是Prumnopitys andina新鲜假种皮中存在的主要植物化学物质。据报道，20E 通过与核受体相互作用调节基因转录而具有合成代谢作用。我们的目的是评估 20E 的体外生物可及性、跨上皮转运，以及安迪那果实提取物和 20E 在模拟胃肠消化后激活瞬时转染人细胞中选定的哺乳动物核受体的能力。

更新日期：2022-10-20

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