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Bio-macromolecular design roadmap towards tough bioadhesives
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-10-21 , DOI: 10.1039/d2cs00618a
Hossein Montazerian 1, 2, 3 , Elham Davoodi 1, 2, 3, 4 , Avijit Baidya 5 , Maryam Badv 2, 6, 7 , Reihaneh Haghniaz 3 , Arash Dalili 8 , Abbas S Milani 8 , Mina Hoorfar 8, 9 , Nasim Annabi 1, 5 , Ali Khademhosseini 3 , Paul S Weiss 1, 2, 6, 10
Affiliation  

Emerging sutureless wound-closure techniques have led to paradigm shifts in wound management. State-of-the-art biomaterials offer biocompatible and biodegradable platforms enabling high cohesion (toughness) and adhesion for rapid bleeding control as well as robust attachment of implantable devices. Tough bioadhesion stems from the synergistic contributions of cohesive and adhesive interactions. This Review provides a biomacromolecular design roadmap for the development of tough adhesive surgical sealants. We discuss a library of materials and methods to introduce toughness and adhesion to biomaterials. Intrinsically tough and elastic polymers are leveraged primarily by introducing strong but dynamic inter- and intramolecular interactions either through polymer chain design or using crosslink regulating additives. In addition, many efforts have been made to promote underwater adhesion via covalent/noncovalent bonds, or through micro/macro-interlock mechanisms at the tissue interfaces. The materials settings and functional additives for this purpose and the related characterization methods are reviewed. Measurements and reporting needs for fair comparisons of different materials and their properties are discussed. Finally, future directions and further research opportunities for developing tough bioadhesive surgical sealants are highlighted.

中文翻译:


坚韧生物粘合剂的生物大分子设计路线图



新兴的无缝线伤口闭合技术导致了伤口处理的范式转变。最先进的生物材料提供生物相容性和可生物降解的平台,具有高内聚力(韧性)和粘附力,可实现快速出血控制以及植入式设备的牢固连接。坚韧的生物粘附源于内聚力和粘附力相互作用的协同作用。本综述为开发坚韧的粘性手术密封剂提供了生物大分子设计路线图。我们讨论了一个材料库和方法来引入生物材料的韧性和粘附力。主要通过聚合物链设计或使用交联调节添加剂引入强而动态的分子间和分子内相互作用来利用本质上坚韧和弹性的聚合物。此外,人们已经做出了许多努力来通过共价/非共价键或通过组织界面处的微观/宏观联锁机制来促进水下粘附。回顾了用于此目的的材料设置和功能添加剂以及相关的表征方法。讨论了公平比较不同材料及其特性的测量和报告需求。最后,强调了开发坚韧的生物粘附性手术密封剂的未来方向和进一步研究机会。
更新日期:2022-10-21
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