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All-fiber biological detection microfluidic chip based on space division and wavelength division multiplexing technologies
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-10-20 , DOI: 10.1039/d2lc00681b Yong Wei 1 , Zhuo Ren 1 , Chunlan Liu 1 , Tianci Jiang 1 , Rui Wang 1 , Chen Shi 1 , Chunbiao Liu 1
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-10-20 , DOI: 10.1039/d2lc00681b Yong Wei 1 , Zhuo Ren 1 , Chunlan Liu 1 , Tianci Jiang 1 , Rui Wang 1 , Chen Shi 1 , Chunbiao Liu 1
Affiliation
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To further reduce the size of a microfluidic detection chip and the sample consumption and to shorten the chip manufacturing cycle, an all-fiber SPR detection multichannel microfluidic chip was proposed and demonstrated in this paper. The microfluidic channel of the proposed chip was provided by the air channel of a double side-hole fiber, the detection unit was fabricated using a dumbbell fiber with a fiber core exposed to air, and the sensing probe was composed and packaged by fiber micro-processing technology. The internal double channels of the fiber constructed from double side-hole and dumbbell fibers can realize dual channel detection based on space division multiplexing. 30 nm silver and 50 nm gold films were respectively coated on the left and right sides of the dumbbell fiber, which can realize the dual channel simultaneous detection based on wavelength division multiplexing. We employed the proposed microfluidic chip to detect immunoglobulin G and dopamine molecules, where the average sensitivity is 0.252 nm (mg mL−1)−1 and 0.061 nm (μg mL−1)−1, and the LOD is 0.397 mg mL−1 and 1.639 μg mL−1, respectively. The microfluidic channel and detection unit of all-fiber multi-channel SPR detection microfluidic chip are provided by a soft and flexible fiber, which is compact in structure, flexible in fabrication and short in manufacturing cycle, making it possible for the microfluidic chip to enter the human body for detection and enabling a new approach for the fabrication of wearable detection microfluidic devices. This provides a new idea for the development of microfluidic chips.
中文翻译：
基于空分波分复用技术的全光纤生物检测微流控芯片
为进一步减小微流控检测芯片的尺寸和样品消耗，缩短芯片制造周期，本文提出并论证了一种全光纤SPR检测多通道微流控芯片。该芯片的微流控通道由双侧孔光纤的空气通道提供，检测单元采用哑铃形光纤制成，纤芯暴露在空气中，传感探头由光纤微孔组成和封装。加工技术。双侧孔和哑铃光纤构建的光纤内部双通道，可以实现基于空分复用的双通道检测。在哑铃纤维的左右两侧分别镀上30nm的银膜和50nm的金膜，可实现基于波分复用的双通道同时检测。我们采用建议的微流控芯片检测免疫球蛋白 G 和多巴胺分子，平均灵敏度为 0.252 nm（mg·mL-1 ) -1和0.061 nm (μg mL -1 ) -1，LOD分别为0.397 mg mL -1和1.639 μg mL -1。全光纤多通道SPR检测微流控芯片的微流控通道和检测单元由柔软、柔韧的光纤提供，结构紧凑、制作灵活、制造周期短，使微流控芯片进入市场成为可能。用于检测的人体，并为可穿戴检测微流体设备的制造提供了一种新方法。这为微流控芯片的发展提供了新的思路。
更新日期：2022-10-20
中文翻译：
基于空分波分复用技术的全光纤生物检测微流控芯片
为进一步减小微流控检测芯片的尺寸和样品消耗，缩短芯片制造周期，本文提出并论证了一种全光纤SPR检测多通道微流控芯片。该芯片的微流控通道由双侧孔光纤的空气通道提供，检测单元采用哑铃形光纤制成，纤芯暴露在空气中，传感探头由光纤微孔组成和封装。加工技术。双侧孔和哑铃光纤构建的光纤内部双通道，可以实现基于空分复用的双通道检测。在哑铃纤维的左右两侧分别镀上30nm的银膜和50nm的金膜，可实现基于波分复用的双通道同时检测。我们采用建议的微流控芯片检测免疫球蛋白 G 和多巴胺分子，平均灵敏度为 0.252 nm（mg·mL-1 ) -1和0.061 nm (μg mL -1 ) -1，LOD分别为0.397 mg mL -1和1.639 μg mL -1。全光纤多通道SPR检测微流控芯片的微流控通道和检测单元由柔软、柔韧的光纤提供，结构紧凑、制作灵活、制造周期短，使微流控芯片进入市场成为可能。用于检测的人体，并为可穿戴检测微流体设备的制造提供了一种新方法。这为微流控芯片的发展提供了新的思路。
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