Recent Advances in Catalytic Asymmetric Syntheses of Functionalized Heterocycles via Halogenation/Chalcogenation of Carbon-Carbon Unsaturated Bonds,Advanced Synthesis & Catalysis

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Recent Advances in Catalytic Asymmetric Syntheses of Functionalized Heterocycles via Halogenation/Chalcogenation of Carbon-Carbon Unsaturated Bonds
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-10-19 , DOI: 10.1002/adsc.202200611
Jun Deng ₁ , Shengshu Liu ₁ , Bing-Qian Zhang ₁ , Wen-Ying Xiao ₁ , Yin-Long Li ₂

Affiliation

Halogen (fluorine, chlorine, bromine, iodine) or chalcogen (sulfur, selenium)-containing heterocycles are widely recognized as key building blocks in many natural products and bioactive targets. Catalytic asymmetric halogenation/chalcogenation of carbon-carbon unsaturated bonds via onium ion transformations are efficient methods to obtain diverse chiral heterocyclic backbones. In the past few years, catalytic enantioselective versions of halo/thio/seleno-functionalizations with various halogen and chalcogen electrophiles have experienced constant development. This review highlights those advances in preparing functionalized heterocycles promoted by chiral organocatalysts or metal-based catalysts.

中文翻译：

碳-碳不饱和键卤化/硫属化催化不对称合成功能化杂环的最新进展

含卤素（氟、氯、溴、碘）或硫属元素（硫、硒）的杂环化合物被广泛认为是许多天然产物和生物活性靶标的关键组成部分。通过鎓离子转化对碳-碳不饱和键进行催化不对称卤化/硫属化是获得多种手性杂环主链的有效方法。在过去的几年中，具有各种卤素和硫族亲电子试剂的卤代/硫代/硒基功能化的催化对映选择性版本不断发展。这篇综述重点介绍了手性有机催化剂或金属基催化剂在制备功能化杂环方面取得的进展。

更新日期：2022-10-19

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