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Polymersomes with Red/Near-Infrared Emission and Reactive Oxygen Species Generation
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2022-10-18 , DOI: 10.1002/marc.202200716
Zhihua Zhang 1 , Hui Chen 1 , Youchao Wang 2 , Nian Zhang 1 , Sylvain Trépout 3 , Ben Zhong Tang 4 , Gilles Gasser 2 , Min-Hui Li 1
Affiliation  

In photodynamic therapy (PDT), the uses of nanoparticles bearing photosensitizers (PSs) can overcome some of the drawbacks of using a PS alone (e.g., poor water solubility and low tumor selectivity). However, numerous nano-formulations are developed by physical encapsulation of PSs through Van der Waals interactions, which have not only a limited load efficiency but also some in vivo biodistribution problems caused by leakage or burst release. Herein, polymersomes made from an amphiphilic block copolymer, in which a PS with aggregation-induced emission (AIE-PS) is covalently attached to its hydrophobic poly(amino acid) block, are reported. These AIE-PS polymersomes dispersed in aqueous solution have a high AIE-PS load efficiency (up to 46% as a mass fraction), a hydrodynamic diameter of 86 nm that is suitable for in vivo applications, and an excellent colloidal stability for at least 1 month. They exhibit a red/near-infrared photoluminescence and ability to generate reactive oxygen species (ROS) under visible light. They are non-cytotoxic in the dark as tested on Hela cells up to concentration of 100 µm. Benefiting from colloidal stability, AIE property and ROS generation capability, such a family of polymersomes can be great candidates for image-guided PDT.

中文翻译:

具有红/近红外发射和活性氧生成的聚合物囊泡

在光动力疗法 (PDT) 中,使用带有光敏剂 (PS) 的纳米粒子可以克服单独使用 PS 的一些缺点(例如,水溶性差和肿瘤选择性低)。然而,许多纳米制剂是通过范德瓦尔斯相互作用物理封装PSs而开发的,这不仅具有有限的负载效率,而且还存在一些由泄漏或突然释放引起的体内生物分布问题。在此,报道了由两亲性嵌段共聚物制成的聚合物囊泡,其中具有聚集诱导发光 (AIE-PS) 的 PS 共价连接到其疏水性聚(氨基酸)嵌段。这些分散在水溶液中的 AIE-PS 聚合物囊泡具有高 AIE-PS 负载效率(质量分数高达 46%),适合体内应用的 86 nm 流体动力学直径,以及至少 1 个月的出色胶体稳定性。它们表现出红色/近红外光致发光和在可见光下产生活性氧 (ROS) 的能力。在 Hela 细胞上测试浓度高达 100 µ 时,它们在黑暗中无细胞毒性。得益于胶体稳定性、AIE 特性和 ROS 生成能力,此类聚合物囊泡家族可以成为图像引导 PDT 的理想候选者。
更新日期:2022-10-18
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