Redox- and pH-Responsive Water-Soluble Flexible Organic Frameworks Realize Synergistic Tumor Photodynamic and Chemotherapeutic Therapy,Macromolecular Rapid Communications

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Redox- and pH-Responsive Water-Soluble Flexible Organic Frameworks Realize Synergistic Tumor Photodynamic and Chemotherapeutic Therapy
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2022-10-17 , DOI: 10.1002/marc.202200690
Yuxin Feng ₁ , Yan Long ₁ , Jiahe Guo ₂ , Xiaofan Yang ₂ , Heng Song _{1,

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Affiliation

Water-soluble 3D polymers with inherent nanoscale pores have been shown to be ideal platforms for the inclusion and delivery of drugs and hold a great promise as biocompatible materials for diagnostic and therapeutic purposes. Herein, a low cytotoxic water-soluble flexible organic framework FOF-S6 with a hydrodynamic diameter of about 127.5 nm is synthesized through the formation of a hydrazone bond from a semirigid tetraaldehyde and a flexible biacylhydrazines which contains a disulfide bond (1:2). FOF-S6 has the ability to dissociate and release inclusion complexes in response to weakly acidic media and glutathione (GSH) overexpressed in tumor cells. More importantly, a facile strategy is developed to contain and deliver aggregation-induced emission photosensitizers (AIE PS, TBD-DQA-540) and chemotherapeutic drugs (Doxorubicin hydrochloride, DOX). DOX-PS@FOF-S6 is synthesized by a one-pot method, which can realize efficient photo-chemotherapy under the guidance of fluorescence imaging, thereby improving the multidrug resistance of tumor cells and the instability of photosensitizers, so as to improve the tumor treatment efficacy.

中文翻译：

氧化还原和 pH 响应水溶性柔性有机框架实现协同肿瘤光动力和化学治疗

具有固有纳米级孔隙的水溶性 3D 聚合物已被证明是用于药物包涵和递送的理想平台，并且作为用于诊断和治疗目的的生物相容性材料具有广阔的前景。在此，通过半刚性四醛和含有二硫键（1:2）的柔性二酰基肼形成腙键，合成了一种低细胞毒性水溶性柔性有机骨架 FOF-S6，其流体动力学直径约为 127.5 nm。FOF-S6 具有解离和释放包合物的能力，以响应弱酸性介质和肿瘤细胞中过表达的谷胱甘肽 (GSH)。更重要的是，开发了一种简便的策略来包含和传递聚集诱导的发射光敏剂（AIE PS，TBD-DQA-540）和化疗药物（盐酸多柔比星，氧）。采用一锅法合成DOX-PS@FOF-S6，可在荧光成像的引导下实现高效的光化学治疗，从而改善肿瘤细胞的多药耐药性和光敏剂的不稳定性，从而改善肿瘤治疗效果。

更新日期：2022-10-17

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