State-of-the-art self-luminescence: a win–win situation,Chemical Society Reviews

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State-of-the-art self-luminescence: a win–win situation
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-10-18 , DOI: 10.1039/d2cs00228k
Mingwang Yang _{1,

2} , Ziling Zeng ₃ , Jacky W Y Lam ₁ , Jiangli Fan ₂ , Kanyi Pu ₃ , Ben Zhong Tang _{1,

4}

Affiliation

Self-luminescence, which eliminates the real-time external optical excitation, can effectively avoid background autofluorescence in photoluminescence, endowing with ultrahigh signal-to-noise ratio and sensitivity in bioassay. Furthermore, in situ generated and emitted photons have been applied to develop excitation-free diagnostics and therapeutic agents against deeply seated diseases. “Enhanced” self-luminescence, referring to the aggregation-induced emission (AIE)-integrated self-luminescence systems, is endowed with not only the above merits but also other superiorities including stronger luminous brightness and longer half-life compared with “traditional” self-luminescence platforms. As an emerging and booming hotspot, the “enhanced” self-luminescence facilitated by the win–win cooperation of the aggregation-induced emission and self-luminescent techniques has become a powerful tool for interdisciplinary research. This tutorial review summarizes the advancements of AIE-assisted self-luminescence including chemiluminescence and afterglow imaging, starting from the discussion on the design and working principles, luminescent mechanisms of self-luminescence fuels, versatile integrated approaches and advantages, and a broad range of representative examples in biosensors and oncotherapy. Finally, the current challenges and perspectives are discussed to further actuate the development of “enhanced” self-luminescence agents for biomedical diagnosis and treatment.

中文翻译：

最先进的自发光：双赢局面

自发光，消除了实时外部光激发，可有效避免光致发光中的背景自发荧光，具有超高的信噪比和生物测定的灵敏度。此外，现场产生和发射的光子已被用于开发针对深层疾病的无激发诊断和治疗剂。“增强型”自发光，是指聚集诱导发射（AIE）集成的自发光系统，与“传统”相比，不仅具有上述优点，而且具有更强的发光亮度和更长的半衰期等优点。自发光平台。作为一个新兴和蓬勃发展的热点，聚集诱导发射和自发光技术的双赢合作促进的“增强型”自发光已成为跨学科研究的有力工具。本教程回顾总结了 AIE 辅助自发光的进展，包括化学发光和余辉成像，从设计和工作原理、自发光燃料的发光机制、多功能综合方法和优势以及生物传感器和肿瘤治疗中的广泛代表性示例的讨论开始。最后，讨论了当前的挑战和前景，以进一步推动用于生物医学诊断和治疗的“增强型”自发光试剂的开发。

更新日期：2022-10-18

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