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Dietary d-Lactate Intake Facilitates Inflammatory Resolution by Modulating M1 Macrophage Polarization
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2022-10-14 , DOI: 10.1002/mnfr.202200196
Yongheng Yan 1 , Xiu Li 1 , Qin Yang 2 , Hao Zhang 1 , Kasper Hettinga 3 , Haitao Li 1 , Wei Chen 1, 2
Affiliation  

Given the d-lactate dehydrogenase (D-LDH) deficiency, L- but not d-lactate is assumed to be the physiological isomer in mammals. Paradoxically, many fermented foods (e.g., yogurt, sauerkraut, cheeses) often contain substantial amounts of d-lactate. In the present study, dietary d-lactate may be a previously unrecognized nutrient aiding in inflammatory resolution is hypothesized.

中文翻译:

膳食 d-乳酸摄入量通过调节 M1 巨噬细胞极化促进炎症消退

鉴于d-乳酸脱氢酶 (D-LDH) 缺乏症,L-而非d-乳酸被认为是哺乳动物的生理异构体。矛盾的是,许多发酵食品(例如酸奶、酸菜、奶酪)通常含有大量的d-乳酸。在本研究中,假设饮食中的d-乳酸可能是一种以前未被认识的有助于炎症消退的营养素。
更新日期:2022-10-14
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