Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late-Stage Type 2 Diabetes Mellitus?,Molecular Nutrition & Food Research

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Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late-Stage Type 2 Diabetes Mellitus?
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-10-10 , DOI: 10.1002/mnfr.202200104
Marina Hernández-Martín _{1,

2} , Aránzazu Bocanegra _{1,

3} , Rocío Redondo-Castillejo _{1,

2} , Adrián Macho-González _{3,

4} , Francisco J Sánchez-Muniz _{3,

4} , Juana Benedí _{1,

3} , Sara Bastida _{3,

4} , Rosa A García-Fernández ₅ , Alba Garcimartín _{1,

3} , M Elvira López-Oliva _{2,

3}

Affiliation

Hypercholesterolemia increases the risk of mortality in type 2 diabetes mellitus (T2DM), especially in the late-stage. Consumption of bioactive compounds as functional ingredients would help achieve therapeutic goals for cholesterolemia. Silicon has demonstrated a hypocholesterolemic effect and the ability to reduce fat digestion. However, it is unclear whether silicon exerts such effect in late-stage T2DM (LD) and the intestinal mechanisms involved.

中文翻译：

十二指肠分子机制是否参与硅作为功能性成分对晚期 2 型糖尿病的降胆固醇作用？

高胆固醇血症会增加 2 型糖尿病 (T2DM) 的死亡风险，尤其是在晚期。食用生物活性化合物作为功能成分将有助于实现胆固醇血症的治疗目标。硅已证明具有降胆固醇作用和减少脂肪消化的能力。然而，尚不清楚硅是否在晚期 T2DM (LD) 中发挥这种作用以及所涉及的肠道机制。

更新日期：2022-10-10

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