Journal of Advanced Research ( IF 11.4 ) Pub Date : 2022-10-05 , DOI: 10.1016/j.jare.2022.09.013 Zhongrui Li 1 , Xiao Xu 2 , Yun Wang 2 , Lingyi Kong 2 , Chao Han 2
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Background
Natural plants as well as traditional Chinese medicine have made outstanding contributions to the health and reproduction of human beings and remain the basis and major resource for drug innovation. Carrier-free nanoplatforms completely self-assembled by pure molecules or therapeutic components have attracted increasing attention due to their advantages of improved pharmacodynamics/pharmacokinetics, reduced toxicity, and high drug loading. In recent years, carrier-free nanoplatforms produced by self-assembly from natural plants have contributed to progress in a variety of therapeutic modalities. Notably, these nanoplatforms based on the interactions of components from different natural plants improve efficiency and depress toxicity.
Aim of Review
In this review, different types of self-assembled nanoplatforms are first summarized, mainly including nanoassemblies of pure small molecules isolated from different plants, extracellular vesicles separated from fresh plants, charcoal nanocomponents obtained from charred plants, and nanoaggregates from plants formulae decoctions.
Key Scientific Concepts of Review: We mainly focus on composition, self-assembly mechanisms, biological activity and modes of action. Finally, a future perspective of existing challenges with respect to the clinical application of plant-based carrier-free nanoplatforms is discussed, which may be instructive to further develop effective carrier-free nanoplatforms from natural plants in the future.
中文翻译：
来自天然植物的无载体纳米平台可增强生物活性
背景
天然植物和中药为人类健康和生殖做出了突出贡献，仍然是药物创新的基础和主要资源。由纯分子或治疗成分完全自组装的无载体纳米平台由于其改善药效/药代动力学、降低毒性和高载药量的优点而受到越来越多的关注。近年来，通过天然植物自组装产生的无载体纳米平台为多种治疗方式的进展做出了贡献。值得注意的是，这些基于不同天然植物成分相互作用的纳米平台提高了效率并降低了毒性。
审查目的
本文首先总结了不同类型的自组装纳米平台，主要包括从不同植物中分离的纯小分子纳米组装体、从新鲜植物中分离的细胞外囊泡、从烧焦的植物中获得的木炭纳米成分以及从植物配方汤剂中提取的纳米聚集体。
综述的关键科学概念：我们主要关注组成、自组装机制、生物活性和作用方式。最后，讨论了植物基无载体纳米平台临床应用中现有挑战的未来前景，这可能对未来进一步开发来自天然植物的有效无载体纳米平台具有指导意义。
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