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Role of non-cardiomyocytes in anticancer drug-induced cardiotoxicity: A systematic review
iScience ( IF 4.6 ) Pub Date : 2022-10-08 , DOI: 10.1016/j.isci.2022.105283 Suifen Xie 1, 2 , Yuanying Yang 1, 2 , Ziheng Luo 3 , Xiangyun Li 1, 2 , Jian Liu 1, 2 , Bikui Zhang 1, 2 , Wenqun Li 1, 2
iScience ( IF 4.6 ) Pub Date : 2022-10-08 , DOI: 10.1016/j.isci.2022.105283 Suifen Xie 1, 2 , Yuanying Yang 1, 2 , Ziheng Luo 3 , Xiangyun Li 1, 2 , Jian Liu 1, 2 , Bikui Zhang 1, 2 , Wenqun Li 1, 2
Affiliation
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Cardiotoxicity induced by anticancer drugs interferes with the continuation of optimal treatment, inducing life-threatening risks or leading to long-term morbidity. The heart is a complex pluricellular organ comprised of cardiomyocytes and non-cardiomyocytes. Although the study of these cell populations has been often focusing on cardiomyocytes, the contributions of non-cardiomyocytes to development and disease are increasingly being appreciated as both dynamic and essential. This review summarized the role of non-cardiomyocytes in anticancer drug-induced cardiotoxicity, including the mechanism of direct damage to resident non-cardiomyocytes, cardiomyocytes injury caused by paracrine modality, myocardial inflammation induced by transient cell populations and the protective agents that focused on non-cardiomyocytes.
中文翻译：
非心肌细胞在抗癌药物引起的心脏毒性中的作用：系统评价
抗癌药物引起的心脏毒性会干扰最佳治疗的持续，引发危及生命的风险或导致长期发病。心脏是一个复杂的多细胞器官，由心肌细胞和非心肌细胞组成。尽管对这些细胞群的研究通常集中在心肌细胞上，但非心肌细胞对发育和疾病的贡献越来越被认为是动态的和重要的。本文综述了非心肌细胞在抗癌药物引起的心脏毒性中的作用，包括对常驻非心肌细胞的直接损伤机制、旁分泌方式引起的心肌细胞损伤、瞬时细胞群诱导的心肌炎症以及针对非心肌细胞的保护剂。 -心肌细胞。
更新日期：2022-10-08
中文翻译：
非心肌细胞在抗癌药物引起的心脏毒性中的作用：系统评价
抗癌药物引起的心脏毒性会干扰最佳治疗的持续，引发危及生命的风险或导致长期发病。心脏是一个复杂的多细胞器官，由心肌细胞和非心肌细胞组成。尽管对这些细胞群的研究通常集中在心肌细胞上，但非心肌细胞对发育和疾病的贡献越来越被认为是动态的和重要的。本文综述了非心肌细胞在抗癌药物引起的心脏毒性中的作用，包括对常驻非心肌细胞的直接损伤机制、旁分泌方式引起的心肌细胞损伤、瞬时细胞群诱导的心肌炎症以及针对非心肌细胞的保护剂。 -心肌细胞。
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