GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes,Molecular Nutrition & Food Research

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GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-10-08 , DOI: 10.1002/mnfr.202200300
Zhaodi Zhang _{1,

2} , Jiahong Li _{1,

2} , Ming Zhang _{1,

2} , Binbin Li _{1,

2} , XiaoHua Pan _{1,

2} , Xiaoliang Dong _{1,

2} , Li-Long Pan ₃ , Jia Sun _{1,

2}

Affiliation

Dietary fibers can alter gut microbiota and microbial metabolite profiles. SCFAs are produced by bacterial fermentation of fiber, mediating immune homeostasis through G-protein-coupled receptors (GPCRs). GPR109a, a receptor for niacin and butyrate, expressed by immune cells and non-immune cells, is a key factor regulating immune responses. However, the role and underlying mechanisms of GPR109a in type 1 diabetes (T1D) remain unclear.

中文翻译：

GPR109a 调节巨噬细胞的表型和功能改变以及 1 型糖尿病的进展

膳食纤维可以改变肠道微生物群和微生物代谢物谱。SCFA 由纤维的细菌发酵产生，通过 G 蛋白偶联受体 (GPCR) 调节免疫稳态。GPR109a 是烟酸和丁酸盐的受体，由免疫细胞和非免疫细胞表达，是调节免疫反应的关键因素。然而，GPR109a 在 1 型糖尿病 (T1D) 中的作用和潜在机制仍不清楚。

更新日期：2022-10-08

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