Injectable, Self-Healing and Multiple Responsive Histamine Modified Hyaluronic Acid Hydrogels with Potentialities in Drug Delivery, Antibacterial and Tissue Engineering,Macromolecular Rapid Communications

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Injectable, Self-Healing and Multiple Responsive Histamine Modified Hyaluronic Acid Hydrogels with Potentialities in Drug Delivery, Antibacterial and Tissue Engineering
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2022-10-07 , DOI: 10.1002/marc.202200674
Sijie Zhou _{1,

2} , Dejun Yang _{1,

2} , Dong Yang ₁ , Yan Guo ₃ , Ronggui Hu ₄ , Yuan Li ₅ , Xingjie Zan _{1,

2} , Xingxing Zhang ₆

Affiliation

Hydrogels are 3D network structures composed of physically or chemically crosslinked, hydrophilic molecules. Compared with conventional hydrogels with static and permanent network structures, injectable and responsive hydrogels generated from dynamic networks, have attracted increasing attention from various disciplines due to their wide-ranging applications in tissue engineering, drug delivery, soft robotics, etc. Herein, an injectable self-healing and multiple-responsive hyaluronic acid (HA)- histamine (His)/metal hydrogel is developed by modifying His onto HA and the subsequent, dynamic coordination between imidazole and metal ions. The pH-responsive and mechanical behaviors exhibited by the HA-His/metal hydrogels are tunable with the kinds and the concentrations of metal ions. The HA-His/Zr⁴⁺ hydrogels demonstrate a moldable capability at a neutral pH and a multi-stimulus-responsive capability when exposed to a weak alkaline environment and hyaluronidase, which inhibits bacterial growth and biofilm formation. Biocompatibilities and accelerated wound healing are demonstrated in vitro and in vivo and are thoroughly investigated and well characterized. The HA-His/Zr⁴⁺ hydrogel has great potential in various biomedical applications, such as pH- and hyaluronidase-responsive sustained release, antibacterial, and implantable materials for tissue engineering.

中文翻译：

可注射、自我修复和多重响应的组胺修饰透明质酸水凝胶，在药物输送、抗菌和组织工程方面具有潜力

水凝胶是由物理或化学交联的亲水分子组成的 3D 网络结构。与具有静态和永久网络结构的传统水凝胶相比，由动态网络生成的可注射和响应水凝胶由于其在组织工程、药物输送、软机器人等方面的广泛应用而引起了各个学科的越来越多的关注。在此，一种可注射的自修复和多重响应透明质酸 (HA)-组胺 (His)/金属水凝胶是通过将 His 修饰到 HA 上以及随后咪唑和金属离子之间的动态配位而开发的。HA-His/金属水凝胶表现出的 pH 响应和机械行为可根据金属离子的种类和浓度进行调节。HA-组氨酸/锆⁴⁺水凝胶在中性 pH 值下表现出可塑性，在暴露于弱碱性环境和透明质酸酶时表现出多重刺激响应能力，抑制细菌生长和生物膜形成。生物相容性和加速伤口愈合在体外和体内得到证实，并得到彻底研究和充分表征。HA-His/Zr ⁴⁺水凝胶在各种生物医学应用中具有巨大潜力，例如 pH 和透明质酸酶响应缓释、抗菌和用于组织工程的植入材料。

更新日期：2022-10-07

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