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Protein desulfurization: Sodium tetraethylborate makes it fast
Chem ( IF 19.1 ) Pub Date : 2022-10-03 , DOI: 10.1016/j.chempr.2022.09.011
Vincent Diemer , Oleg Melnyk

Today, the development of powerful one-pot techniques combining native chemical ligation and cysteine reductive desulfurization is central to the production of proteins by chemical synthesis. In the September issue of Chem, Xuechen Li and co-workers achieved this goal by combining sodium tetraethylborate and a phosphine as a post-ligation treatment.



中文翻译:

蛋白质脱硫:四乙硼酸钠使其快速脱硫

今天,结合天然化学连接和半胱氨酸还原脱硫的强大一锅技术的发展是化学合成生产蛋白质的核心。在Chem的 9 月刊中,Xuechen Li 和同事通过将四乙基硼酸钠和磷化氢结合作为连接后处理实现了这一目标。

更新日期:2022-10-03
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