Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria,Angewandte Chemie International Edition

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Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-10-05 , DOI: 10.1002/anie.202206106
Yi-Ming Shi _{1,

2} , Jan J Crames _{1,

2} , Laura Czech ₃ , Kenan A J Bozhüyük _{1,

2} , Yan-Ni Shi _{1,

2} , Merle Hirschmann ₂ , Stefanie Lamberth ₂ , Peter Claus ₄ , Nicole Paczia ₄ , Christian Rückert ₅ , Jörn Kalinowski ₅ , Gert Bange ₃ , Helge B Bode _{1,

2,

6,

7}

Affiliation

Benzoxazolinate is a rare bis-heterocyclic moiety that interacts with proteins and DNA. It was found that a putative acyl AMP-ligase mediates the last cyclization step to afford benzoxazolinate. The enzyme was then used as a probe for genome mining, which led to the discovery of a new class of benzoxazolinate-containing compounds in diverse bacteria.

中文翻译：

通过生物合成表征实现的基因组挖掘在多种细菌中发现了一类含苯并恶唑啉酸盐的天然产物

Benzoxazolinate 是一种罕见的双杂环部分，可与蛋白质和 DNA 相互作用。发现推定的酰基 AMP 连接酶介导最后的环化步骤以提供苯并恶唑啉酸盐。然后将该酶用作基因组挖掘的探针，从而在多种细菌中发现了一类新的含苯并恶唑啉酸盐的化合物。

更新日期：2022-10-05

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