A noninvasive method to quantify the impairment of spinal motion ability in Parkinson’s disease,European Spine Journal

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A noninvasive method to quantify the impairment of spinal motion ability in Parkinson’s disease
European Spine Journal ( IF 2.6 ) Pub Date : 2022-10-04 , DOI: 10.1007/s00586-022-07401-w
Philipp Spindler ₁ , Yasmin Alzoobi ₁ , Peter Truckenmüller ₁ , Sabine Hahn ₂ , Yves N Manzoni ₃ , Lucia Feldmann ₄ , Kay-Geert Hermann ₃ , Andrea A Kühn ₄ , Katharina Faust ₁ , Gerd-Helge Schneider ₁ , Peter Vajkoczy ₁ , Hendrik Schmidt ₂

Affiliation

Purpose

There is a high demand on spinal surgery in patients with Parkinson’s disease (PD) but the results are sobering. Although detailed clinical and radiological diagnostics were carried out with great effort and expense, the biodynamic properties of the spine of PD patients have never been considered. We propose a noninvasive method to quantify the impairment of motion abilities in patients with PD.

Methods

We present an analytical cross-sectional study of 21 patients with severe PD. All patients underwent a biodynamic assessment during a standardized movement-choreography. Thus, individual spinal motion profiles of each patient were objectively assessed and compared with a large comparative cohort of individuals without PD. Moreover, clinical scores to quantify motor function and lumbar back pain were collected and X-ray scans of the spine in standing position were taken and analysed.

Results

Biodynamic measurement showed that 36.9% of the assessed motions of all PD patients were severely impaired. Men were generally more functionally impaired than women, in 52% of all motion parameters. The neurological and radiological diagnostics recorded pathological values, of which UPDRS-III ON correlated with findings of the biodynamics assessment (R = 0.52, p = 0.02).

Conclusions

The decision to operate on a PD patient’s spine is far-reaching and requires careful consideration. Neurological and radiological scores did not correlate with the biodynamics of the spine. The resulting motion profile could be used as individual predictive factor to estimate whether patients are eligible for spinal surgery or alternative therapies.

中文翻译：

一种量化帕金森病脊柱运动能力损伤的无创方法

目的

帕金森病 (PD) 患者对脊柱手术的需求很高，但结果令人震惊。尽管付出了巨大的努力和费用进行了详细的临床和放射学诊断，但从未考虑过 PD 患者脊柱的生物动力学特性。我们提出了一种非侵入性方法来量化 PD 患者运动能力的损伤。

方法

我们对 21 名重度 PD 患者进行了分析性横断面研究。所有患者都在标准化动作编排过程中接受了生物动力学评估。因此，客观地评估了每个患者的个体脊柱运动特征，并与没有 PD 的个体的大型比较队列进行了比较。此外，还收集了量化运动功能和腰背痛的临床评分，并对站立位的脊柱进行了 X 射线扫描并进行了分析。