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Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model.
Journal of Orthopaedic Translation ( IF 5.9 ) Pub Date : 2022-09-10 , DOI: 10.1016/j.jot.2022.07.008
Yudie Chen 1 , Yu Sun 2 , Xinhui Wu 1 , Jie Lou 2 , Xiaonong Zhang 2, 3 , Zhaoxiang Peng 1
Affiliation  

Background Rotator cuff tear has become one of the diseases affecting people's living quality. Conventional anchor materials such as titanium alloy and poly-lactic acid can lead to postoperative complications like bone defects and aseptic inflammation. Magnesium (Mg)-based implants are biodegradable and biocompatible, with strong potential to be applied in orthopaedics. Methods In this study, we developed a high-purity (HP) Mg suture anchor and studied its mechanical properties and degradation behavior in vitro. Furthermore, we described the use of high-purity Mg to prepare suture anchor for the rotator cuff repair in sheep. Results The in vitro tests showed that HP Mg suture anchor possess proper degradation behavior and appropriate mechanical property. Animal experiment indicated that HP Mg suture anchor provided reliable anchoring function in 12 weeks and showed no toxic effect on animal organs. Conclusion In summary, the HP Mg anchor presented in this study had favorable mechanical property and biosecurity.The translational potential of this article: The translational potential of this article is to use high-purity Mg to develop a degradable suture anchor and verify the feasibility of the application in animal model. This study provides a basis for further research on the clinical application of biodegradable high-purity Mg suture anchor.

中文翻译:

在绵羊模型中使用可生物降解的高纯度镁缝合锚修复肩袖。

背景技术肩袖撕裂已成为影响人们生活质量的疾病之一。钛合金和聚乳酸等传统锚固材料会导致术后并发症,如骨缺损和无菌性炎症。镁 (Mg) 基植入物具有生物可降解性和生物相容性,具有在骨科中应用的巨大潜力。方法在本研究中,我们开发了一种高纯度(HP)镁缝合锚,并在体外研究了其力学性能和降解行为。此外,我们描述了使用高纯度镁制备用于羊肩袖修复的缝合锚。结果体外试验表明,HP Mg缝合锚具有良好的降解行为和良好的力学性能。动物实验表明,HP Mg缝合锚在12周内提供了可靠的锚定功能,对动物器官无毒性作用。结论综上所述,本研究提出的HP Mg锚具有良好的力学性能和生物安全性。本文的转化潜力:本文的转化潜力是利用高纯度Mg开发可降解缝合锚并验证其可行性。动物模型中的应用。本研究为进一步研究可生物降解高纯度镁缝合锚钉的临床应用提供依据。本文的转化潜力在于利用高纯度镁开发可降解缝合锚钉并验证在动物模型中应用的可行性。本研究为进一步研究可生物降解高纯度镁缝合锚钉的临床应用提供依据。本文的转化潜力在于利用高纯度镁开发可降解缝合锚钉并验证在动物模型中应用的可行性。本研究为进一步研究可生物降解高纯度镁缝合锚钉的临床应用提供依据。
更新日期:2022-09-10
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