A new study has identified a scavenger receptor-independent mechanism of atherosclerosis development by showing that LDL uptake through macropinocytosis contributes to macrophage foam cell formation and atherosclerosis development and that an FDA-approved drug that inhibits macropinocytosis inhibits atherosclerosis development in mice.

中文翻译：

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巨胞饮作用促进泡沫细胞形成和动脉粥样硬化

一项新的研究表明，通过巨胞饮作用摄取低密度脂蛋白有助于巨噬细胞泡沫细胞的形成和动脉粥样硬化的发展，并且 FDA 批准的抑制巨胞饮作用的药物可抑制小鼠动脉粥样硬化的发展，从而确定了动脉粥样硬化发展的清道夫受体非依赖性机制。