The relationship between sarcopenia-related measurements and osteoporosis: The SARCOP study,Osteoporosis International

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The relationship between sarcopenia-related measurements and osteoporosis: The SARCOP study
Osteoporosis International ( IF 4.2 ) Pub Date : 2022-10-04 , DOI: 10.1007/s00198-022-06563-z
Tülay Tiftik ₁ , Murat Kara ₂ , Esra Gizem Koyuncu ₂ , Bayram Kaymak ₂ , Ömer Faruk Çelik ₁ , İrem Çiftçi ₁ , Gizem Olgu Korkmaz ₂ , Pelin Analay ₂ , Mahmud Fazıl Aksakal ₂ , Hasan Ocak ₂ , Cevriye Mülkoğlu ₁ , Hakan Genç ₁ , Ayşen Akıncı ₂ , Levent Özçakar ₂

Affiliation

Summary

As muscle and bone are closely-related, we have explored the association between sarcopenia-related measurements and bone mineral density (BMD) (and osteoporosis) in postmenopausal women. Grip strength, anterior thigh muscle thickness and chair stand test were found to be related with BMD. Additionally, grip strength < 22 kg increased the odds ratio of osteoporosis 1.6 times.

Introduction

As muscle and bone are two closely related tissues, we aimed to investigate the association between sarcopenia-related measurements (i.e., sonographic anterior thigh muscle thickness, grip strength, chair stand test (CST), gait speed) and clinical factors, lumbar/femoral BMD, and the presence of osteoporosis (OP) in postmenopausal women.

Methods

Community dwelling postmenopausal women from two physical and rehabilitation medicine outpatient clinics were consecutively included in this cross-sectional study. Demographic data, age, weight, height, education/exercise status, smoking, and comorbidities were registered. BMD measurements were performed from lumbar vertebrae (L1-4) and femoral neck using dual energy X-ray absorptiometry (DXA). A T-score of ≤ -2.5 SD in the lumbar vertebrae (L1-L4) and/or femoral neck was accepted as OP. Anterior thigh muscle thickness (MT) at the midthigh level was measured sonographically using a linear probe. Grip strength was measured from the dominant side. Physical performance was assessed by CST and gait speed.

Results

Among 546 postmenopausal women, 222 (40.7%) had OP. Among sarcopenia-related parameters, grip strength and anterior thigh MT were positively associated with lumbar vertebral BMD. CST performance was positively associated with femoral neck BMD. After adjusting for confounding factors, low grip strength (< 22 kg) increased 1.6 times the risk of OP.

Conclusion

Loss of muscle mass/function (i.e., sarcopenia) can coexist with loss of trabecular and cortical bone. To this end, grip strength and anterior thigh MT seem to be associated with the lumbar vertebral BMD, while CST is associated with the femoral neck BMD. Lastly, low grip strength might have an association with postmenopausal OP.

中文翻译：

肌肉减少症相关测量值与骨质疏松症之间的关系：SARCOP 研究

概括

由于肌肉和骨骼密切相关，我们探索了绝经后妇女肌肉减少症相关测量值与骨矿物质密度 (BMD)（和骨质疏松症）之间的关联。发现握力、大腿前侧肌肉厚度和椅子站立试验与 BMD 相关。此外，握力 < 22 公斤会使骨质疏松症的几率比增加 1.6 倍。

介绍

由于肌肉和骨骼是两个密切相关的组织，我们旨在研究肌肉减少症相关测量值（即超声检查大腿前部肌肉厚度、握力、椅子站立测试 (CST)、步态速度）与临床因素、腰椎/股骨之间的关联BMD，以及绝经后妇女骨质疏松症 (OP) 的存在。

方法

来自两个物理和康复医学门诊诊所的社区居住的绝经后妇女被连续纳入这项横断面研究。登记了人口统计数据、年龄、体重、身高、教育/运动状况、吸烟和合并症。使用双能 X 射线吸收测定法 (DXA) 从腰椎 (L1-4) 和股骨颈进行 BMD 测量。腰椎 (L1-L4) 和/或股骨颈的 T 分数≤ -2.5 SD 被认为是 OP。大腿前部肌肉厚度 (MT) 在大腿中部水平使用线性探头超声测量。握力是从优势侧测量的。通过 CST 和步态速度评估身体表现。