For many people who think that depression is caused by low serotonin, an antidepressant “working” means that it corrects their serotonin system.1 The honest message to such patients is that their serotonin system is likely to be more abnormal after treatment than before.2 This might be a risk worth taking if there were evidence that the drugs saved lives …

中文翻译：

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在抗抑郁药的情况下，“工作”是什么意思？

对于许多认为抑郁症是由低血清素引起的人来说，抗抑郁药“起作用”意味着它可以纠正他们的血清素系统。 1 对这些患者的诚实信息是，他们的血清素系统在治疗后可能比治疗前更加异常。 2如果有证据表明药物可以挽救生命，这可能是值得冒的风险……